Semisynthesis and Cytotoxicity of Hypothemycin Analogues

Evaluation of the hypothemycin cytotoxicity SAR identifies the C4′–C8′ region of the macrocyclic lactone as relatively intolerant of structural modifications. Manipulation of the 4-position of the resorcylic acid, however, provides new opportunities to improve solubility and pharmacokinetic properties as this site may be modified without negatively impacting cytotoxicity. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2007/z700128_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.