脂肪生成
内分泌学
脂肪酸合成
内科学
生物
酶
化学
生物化学
脂质代谢
医学
作者
Irfan J. Lodhi,Xiaochao Wei,Clay F. Semenkovich
标识
DOI:10.1016/j.tem.2010.09.002
摘要
De novo lipogenesis, the production of fats from simple precursors, is often dismissed as irrelevant to the pathobiology of obesity caused by positive energy balance due to typical high fat diets. However, emerging data implicate de novo lipogenesis in the generation of metabolic signals that alter disease risk. Exploiting this signaling pathway represents lipoexpediency. Lipoexpediency is the concept of directing fats toward benefit even in the setting of lipid overload, and represents a strategy to complement efforts aimed at improving energy balance. Optimizing lipid signals initiated by key lipogenic enzymes such as fatty acid synthase might limit morbidity in people who are unlikely to abandon the lifestyle of the sedentary gourmand.
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