生物
尼泊金甲酯
生殖力
卵黄原蛋白
尼泊金丙酯
黑腹果蝇
蜕皮激素受体
基因表达
蛋黄
雌激素受体
蜕皮激素
防腐剂
基因
内科学
内分泌学
植物
激素
生物化学
遗传学
食品科学
核受体
转录因子
人口
乳腺癌
人口学
社会学
癌症
医学
作者
Ting Liu,Yajuan Li,Xiaojun Zhao,Min Zhang,Wei Gu
标识
DOI:10.1016/j.jinsphys.2014.09.008
摘要
Parabens, which mainly include methylparaben (MP), ethylparaben (EP), propylparaben (PP), and butylparaben (BP), are widely used as cosmetic and food preservatives. Although these chemicals, when used as preservatives, are thought to be safe for humans, many studies have demonstrated that they have estrogenic effects, and can affect the normal development and functions of the reproductive systems in a number of animal species. By treating fruit flies (Drosophila melanogaster) with EP, here we show that lower concentration of EP (0.02%) enhanced fertility while higher concentration of EP (0.10% and 0.20%) shortened the lifespan and reduced the fecundity of fruit flies. When we analyzed the expression levels of the estrogen-related receptor gene (ERR), ecdysone receptor gene (EcR) and Yolk protein receptor gene (YPR) from control and EP-treated fruit flies by using quantitative real-time PCR, we found that the expression levels of all three genes were significantly changed by EP treatment, and that female fruit flies are more sensitive to EP than males. Our data suggests that the estrogenic and the toxic effects of EP to fruit flies may have a molecular basis through the hormonal effect of EP.
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