Platensimycin and its relatives: A recent story in the struggle to develop new naturally derived antibiotics

In this review the isolation, occurrence, structure elucidation, chemical properties, biosynthesis and chemical synthesis of the naturally occurring cage-like antibiotics platensimycin, platencin, isoplatensimycin, platensimycin A 1 , and platensimycin B 1 –B 3 , as well as several synthetic analogues, are described. The literature up to 2010 is reviewed and 139 references are cited.