长非编码RNA
上皮-间质转换
癌症研究
自分泌信号
下调和上调
转移
转化生长因子
信号转导
生物
肝细胞癌
车站3
癌症
细胞培养
基因
细胞生物学
遗传学
生物化学
作者
Ji‐hang Yuan,Fusheng Yang,Fang Wang,Jinzhao Ma,Yingjun Guo,Qi-Fei Tao,Feng Liu,Wei Pan,Tian Wang,Chuanchuan Zhou,Shaobing Wang,Yu‐Zhao Wang,Yuan Yang,Ning Yang,Weiping Zhou,Guang-Shun Yang,Shuhan Sun
出处
期刊:Cancer Cell
[Elsevier]
日期:2014-05-01
卷期号:25 (5): 666-681
被引量:1313
标识
DOI:10.1016/j.ccr.2014.03.010
摘要
The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still unknown. In this study, we observed that the lncRNA-activated by TGF-β (lncRNA-ATB) was upregulated in hepatocellular carcinoma (HCC) metastases and associated with poor prognosis. lncRNA-ATB upregulated ZEB1 and ZEB2 by competitively binding the miR-200 family and then induced EMT and invasion. In addition, lncRNA-ATB promoted organ colonization of disseminated tumor cells by binding IL-11 mRNA, autocrine induction of IL-11, and triggering STAT3 signaling. Globally, lncRNA-ATB promotes the invasion-metastasis cascade. Thus, these findings suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for antimetastatic therapies.
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