De Novo Asymmetric Synthesis of the Anthrax Tetrasaccharide by a Palladium‐Catalyzed Glycosylation Reaction

Choose your poison: In the de novo asymmetric synthesis of the anthrax tetrasaccharide 1 (25 steps from acetylfuran), the absolute configurations of three L sugars and one D sugar were set by the Noyori reduction of acetylfuran with the S,S and the R,R reagent, respectively. The configuration of the remaining carbohydrate unit was set by highly diastereoselective palladium-catalyzed glycosylation and post-glycosylation transformations. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z701354_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.