内质网
生物
细胞生物学
细胞质
细胞内
突变体
膜蛋白
细胞膜
膜
生物化学
基因
作者
Hiroshi Takeshima,Shinji Komazaki,Miyuki Nishi,Masamitsu Iino,Kenji Kangawa
出处
期刊:Molecular Cell
[Elsevier]
日期:2000-07-01
卷期号:6 (1): 11-22
被引量:318
标识
DOI:10.1016/s1097-2765(00)00003-4
摘要
Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/ SR) are a common feature of all excitable cell types and mediate cross-talk between cell surface and intracellular ion channels. We have identified the junctophilins (JPs), a novel conserved family of proteins that are components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. In mouse, there are at least three JP subtypes: JP-1, -2, and -3. JP-2 is abundantly expressed in the heart, and mutant mice lacking JP-2 exhibited embryonic lethality. Cardiac myocytes from the mutant mice showed deficiency of the junctional membrane complexes and abnormal Ca2+ transients. Our results suggest that JPs are important components of junctional membrane complexes.
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