胃排空
运动性
兴奋剂
内科学
药理学
西沙必利
受体拮抗剂
内分泌学
阿托品
生物
医学
敌手
胃
受体
遗传学
作者
Yoshiyuki Kimura,Maho Sumiyoshi
标识
DOI:10.1016/j.jep.2012.02.031
摘要
The rhizomes of Atractylodes lancea DC (Compositae) are used clinically to treat gastrointestinal symptoms, including functional dyspepsia and gastroparesis, in China and Japan, but their influence and mechanism on gastrointestinal motility are not yet proven in detail. This study examined the effects of an Atractylodes lancea extract, and isolated β-eudesmol, on gastric emptying and small intestinal motility in atropine-, dopamine-, and 5-hydroxytryptamine (5-HT)-treated mice. The extract (500 or 1000 mg/kg) and β-eudesmol (50 or 100 mg/kg), as well as itopride hydrochloride (a dopamine D2 receptor antagonist, 10 or 50 mg/kg), stimulated small intestinal motility in normal mice. They inhibited reductions in gastric emptying and gastrointestinal motility induced by dopamine (1 mg/kg, intraperitoneal injection, ip). The extract (1000 mg/kg) and β-eudesmol (100 mg/kg) inhibited the atropine-induced decrease in small intestinal motility, but not gastric emptying. Furthermore, the extract (500 or 1000 mg/kg) and β-eudesmol (25, 50, or 100 mg/kg) inhibited reductions in gastric emptying and small intestinal motility caused by 5-HT (4 mg/kg, ip) or the 5-HT3 receptor agonist 1-(3-chlorophenyl) biguanide (0.5 mg/kg, ip), but not a 5-HT2C receptor agonist. These findings suggest that the extract of Atractylodes lancea and β-eudesmol may stimulate gastric emptying or small intestinal motility by inhibiting the dopamine D2 receptor and 5-HT3 receptor.
科研通智能强力驱动
Strongly Powered by AbleSci AI