磁刺激
运动皮层
神经科学
刺激
诱发电位
癫痫
沉默期
大脑皮层
心理学
医学
作者
R. Chen,Joseph Claßen,Christian Gerloff,Pablo Celnik,Eric M. Wassermann,Mark Hallett,Leonardo G. Cohen
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:1997-05-01
卷期号:48 (5): 1398-1403
被引量:1919
标识
DOI:10.1212/wnl.48.5.1398
摘要
We studied the effects of low-frequency transcranial magnetic stimulation (TMS) on motor cortex excitability in humans. TMS at 0.1 Hz for 1 hour did not change cortical excitability. Stimulation at 0.9 Hz for 15 minutes (810 pulses), similar to the parameters used to induce long-term depression (LTD) in cortical slice preparations and in vivo animal studies, led to a mean decrease in motor evoked potential (MEP) amplitude of 19.5%. The decrease in cortical excitability lasted for at least 15 minutes after the end of the 0.9 Hz stimulation. The mechanism underlying this decrease in excitability may be similar to LTD. TMS-induced reduction of cortical excitability has potential clinical applications in diseases such as epilepsy and myoclonus. Spread of excitation, which may be a warning sign for seizures, occurred in one subject and was not accompanied by increased MEP amplitude, suggesting that spread of excitation and amplitude changes are different phenomena and also indicating the need for adequate monitoring even with stimulations at low frequencies.
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