树突状细胞
免疫系统
癌症免疫疗法
佐剂
免疫疗法
生物
免疫
肿瘤微环境
免疫学
免疫检查点
获得性免疫系统
作者
Hae Young Park,Mitra Ashayeri-Panah,Michaël Chopin
标识
DOI:10.1016/j.coi.2023.102341
摘要
Dendritic cells (DCs) are ubiquitous immune cells endowed with a unique capacity to initiate antigen-specific immunity and tolerance. Owing to their unique functional attributes, DCs have long been considered ideal candidates for the induction of effective antitumour responses. At the forefront of the cancer-immunity cycle, attempts to harness DC natural adjuvant properties in the clinic have resulted so far in suboptimal antitumour responses. A better understanding of the heterogeneity of the DC network and its dynamics within the tumour microenvironment will provide a blueprint to fully capitalise on their functional properties to achieve more effective antitumour responses. In this review, we will briefly summarise the origin and heterogeneity of the DC network, their roles in shaping antitumour immunity and in modulating the response to immune checkpoint blockade therapies.
科研通智能强力驱动
Strongly Powered by AbleSci AI