The expression and function of growth hormone secretagogue receptor in immune cells: A current perspective

生长素 产矿性 炎症 免疫系统 生长激素促分泌素受体 受体 激素 生物 信号转导 内分泌学 免疫学 内科学 细胞生物学 医学 神经肽Y受体 神经肽
作者
Ji Yeon Noh,Matthew Herrera,Bhimanagouda S. Patil,Xiao‐Di Tan,Gus A. Wright,Yuxiang Sun
出处
期刊:Experimental Biology and Medicine [SAGE Publishing]
卷期号:247 (24): 2184-2191 被引量:9
标识
DOI:10.1177/15353702221121635
摘要

The orexigenic hormone ghrelin and its receptor, growth hormone secretagogue receptor (GHS-R), have been extensively studied in the last two decades, revealing that ghrelin signaling has important implications in health and disease. Metabolic diseases, such as obesity and diabetes, are often accompanied by low-grade chronic inflammation, that has been coined as “meta-inflammation.” Immune cells are key cellular mediators of meta-inflammation, controlling both initiation and resolution of inflammation. Immune cells exhibit dynamic changes in cellular characteristics and functional output in response to the stimuli/insults from their surrounding microenvironment. Emerging evidence shows that ghrelin has an important effect on inflammation, in addition to its well-known effects on metabolism. However, the cellular/molecular mechanism of ghrelin signaling in immunity is largely unknown because the knowledge in regard to the expression and function of GHS-R in immune cells is currently sparse. In this review, we have accumulated the recent findings related to the expression and functions of GHS-R in various immune cells under different physiological and pathological states. This review aims to inspire further investigation of the immunological roles of ghrelin signaling and advance the therapeutic applications of ghrelin signaling in meta-inflammation.

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