Feature selection (FS) aims to eliminate redundant features and choose the informative ones. Since labeled data are not always easily available and abundant unlabeled data are often accessible, the importance of semi-supervised FS (SSFS), which selects the informative features utilizing the labeled and unlabeled data, becomes apparent. Semi-supervised sparse FS based on graph Laplacian (GL) regularization has become a popular technique. The GL regularization biases the solution towards a constant geodesic function, has a poor extrapolating ability, and cannot preserve well the topological structure of data. Traditional ridge regression is widely utilized by the GL-based semi-supervised sparse FS, but the results cannot gain the closed-form solution and carry out the manifold structure. To tackle these problems, we propose a Hessian-based SSFS framework using the generalized uncorrelated constraint (HSFSGU) and the mixed ℓ2,p-norm (0