冲程(发动机)
物理医学与康复
康复
功能近红外光谱
慢性中风
心理学
医学
静息状态功能磁共振成像
神经科学
认知
前额叶皮质
机械工程
工程类
作者
Congcong Huo,Gelin Xu,Hua Xie,Haihong Zhao,Xuemin Zhang,Wenhao Li,Simin Zhang,Jianfei Huo,Huiyuan Li,Aiping Sun,Zengyong Li
出处
期刊:Brain Research
[Elsevier]
日期:2023-06-01
卷期号:1809: 148357-148357
被引量:2
标识
DOI:10.1016/j.brainres.2023.148357
摘要
Neurological evidence for the combinational intervention coupling rTMS with motor training for stroke rehabilitation remains limited. This study aimed to investigate the effects of rTMS combined with bilateral arm training (BAT) on the brain functional reorganization in patients with chronic stroke via functional near-infrared spectroscopy (fNIRS).Fifteen stroke patients and fifteen age-matched healthy participants were enrolled and underwent single BAT session (s-BAT) and BAT immediately after 5-Hz rTMS over the ipsilesional M1 (rTMS-BAT), measured cerebral haemodynamics by fNIRS. Functional connectivity (FC), the clustering coefficient (Ccoef), and local efficiency (Eloc) were applied to evaluate the functional response to the training paradigms.The differences in FC responses to the two training paradigms were more pronounced in stroke patients than in healthy controls. In the resting state, stroke patients exhibited significantly lower FC than controls in both hemispheres. rTMS-BAT induced no significant difference in FC between groups. Compared to the resting state, rTMS-BAT induced significant decreases in Ccoef and Eloc of the contralesional M1 and significant increases in Eloc of the ipsilesional M1 in stroke patients. Additionally, these above two network metrics of the ipsilesional motor area were significantly positively correlated with the motor function of stroke patients.These results suggest that the rTMS-BAT paradigm had additional effects on task-dependent brain functional reorganization. The engagement of the ipsilesional motor area in the functional network was associated with the motor impairment severity of stroke patients. fNIRS-based assessments may provide information about the neural mechanisms underlying combination interventions for stroke rehabilitation.
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