胞浆
钙信号传导
细胞生物学
线粒体
线粒体基质
氧化磷酸化
生物
信号转导
细胞质
逆行信号
线粒体融合
线粒体DNA
生物化学
基因
酶
作者
Melissa J S MacEwen,Yasemin Sancak
出处
期刊:Biochemical Society Transactions
[Portland Press]
日期:2023-03-24
卷期号:51 (2): 665-673
摘要
Mitochondrial calcium (Ca2+) signaling has long been known to regulate diverse cellular functions, ranging from ATP production via oxidative phosphorylation, to cytoplasmic Ca2+ signaling to apoptosis. Central to mitochondrial Ca2+ signaling is the mitochondrial Ca2+ uniporter complex (MCUC) which enables Ca2+ flux from the cytosol into the mitochondrial matrix. Several pivotal discoveries over the past 15 years have clarified the identity of the proteins comprising MCUC. Here, we provide an overview of the literature on mitochondrial Ca2+ biology and highlight recent findings on the high-resolution structure, dynamic regulation, and new functions of MCUC, with an emphasis on publications from the last five years. We discuss the importance of these findings for human health and the therapeutic potential of targeting mitochondrial Ca2+ signaling.
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