铁载体
肺炎克雷伯菌
头孢菌素
生物
微生物学
最小抑制浓度
抗菌剂
克雷伯菌
抗生素
细菌
大肠杆菌
遗传学
基因
作者
Peng Lan,Ye Lu,Yan Jiang,Xueqing Wu,Yunsong Yu,Jiancang Zhou
标识
DOI:10.1016/j.ijantimicag.2022.106646
摘要
Cefiderocol is a cephalosporin antibiotic presenting expanded antimicrobial activity. CirA is a gateway for cefiderocol to enter bacterial cells. We found that cirA1 and cirA198 were primary alleles in Klebsiella pneumoniae. CirA1 exhibited higher iron-transporting ability than CirA198 in iron-limited conditions. The cefiderocol minimum inhibitory concentration (MIC) increased from 0.5 mg/L to 2 mg/L when cirA1 was mutated to cirA198. Consistently, the MIC showed a 4-fold decrease when cirA198 was mutated to cirA1. Therefore, CirA1 has higher capacity to transport siderophores, contributing to increased cefiderocol susceptibility.
科研通智能强力驱动
Strongly Powered by AbleSci AI