渴求
线索反应性
心理学
感觉
反应性(心理学)
功能磁共振成像
酒
腹侧纹状体
意识的神经相关物
临床心理学
观察研究
发展心理学
精神科
认知
纹状体
上瘾
医学
社会心理学
神经科学
内科学
化学
替代医学
病理
多巴胺
生物化学
作者
Yoona Kang,Danielle Cosme,David M. Lydon‐Staley,Jeesung Ahn,Mia Jovanova,Faustine Corbani,Silicia Lomax,Ovidia Stanoi,Victor J. Strecher,Peter J. Mucha,Kevin N. Ochsner,Dani S. Bassett,Emily B. Falk
出处
期刊:Addiction
[Wiley]
日期:2022-08-22
卷期号:117 (12): 3049-3057
被引量:5
摘要
Alcohol craving is an urge to consume alcohol that commonly precedes drinking; however, craving does not lead to drinking for all people under all circumstances. The current study measured the correlation between neural reactivity and alcohol cues as a risk, and purpose in daily life as a protective factor that may influence the link between alcohol craving and the subsequent amount of consumption.Observational study that correlated functional magnetic resonance imaging (fMRI) data on neural cue reactivity and ecological momentary assessments (EMA) on purpose in life and alcohol use.Two college campuses in the United States.A total of 54 college students (37 women, 16 men, and 1 other) recruited via campus-based groups from January 2019 to October 2020.Participants underwent fMRI while viewing images of alcohol; we examined activity within the ventral striatum, a key region of interest implicated in reward and craving. Participants then completed 28 days of EMA and answered questions about daily levels of purpose in life and alcohol use, including how much they craved and consumed alcohol.A significant three-way interaction indicated that greater alcohol cue reactivity within the ventral striatum was associated with heavier alcohol use following craving in daily life only when people were previously feeling a lower than usual sense of purpose. By contrast, individuals with heightened neural alcohol cue reactivity drank less in response to craving if they were feeling a stronger than their usual sense of purpose in the preceding moments (binteraction = -0.086, P < 0.001, 95% CI = -0.137, -0.035).Neural sensitivity to alcohol cues within the ventral striatum appears to be a potential risk for increased alcohol use in social drinkers, when people feel less purposeful. Enhancing daily levels of purpose in life may promote alcohol moderation among social drinkers who show relatively higher reactivity to alcohol cues.
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