5-Methylated polyprenylated acylphloroglucinol derivatives as low-voltage-gated Ca2+ channel inhibitors

Twenty-seven PPAPs (1–27), all decorated with a methyl group at C-5, were identified from Hypericum ascyron L. Compounds 1–3 are characterized by an unusual cyclopentane framework. Several compounds exhibited potent inhibition of LVGCCs.