Synthesis and in vitro oral anti-inflammatory activity of pH-sensitive baicalin liposomes

In recent years, clinicians have faced significant challenges in applying baicalin. This issue primarily arises from its low solubility and brief half-life. Thus, developing new baicalin drug delivery system has become an urgent task to address this obstacle. Liposomes system has been regarded as promising drug carriers due to their low adverse effects, non-immunogenicity and biodegradability. This study explored the possibility of utilizing Dioleoyl phosphatidylethanolamine (DOPE) and Cholesteryl hemisuccinate (CHEMS) liposomes as nanocarriers loaded baicalin to exhibit anti-inflammatory in patients with periodontitis. In our research, the pH-sensitive baicalin liposomes (pH-Bai-Lips) were successfully prepared and characterized for the particle size, zeta potential, morphology, encapsulation efficiency, in vitro release study and acid responsiveness. The in vitro results indicated that pH-Bai-Lips could be promising carriers for periodontitis treatment due to efficient drug delivery and effective conditional response release performance.