Development of a scalable and sustainable continuous-flow microreaction process for mononitration of aromatic compounds with high selectivity and yield

. Under the same reaction conditions, the yield and selectivity were consistent with, or even improved over, those obtained in small-scale experiments, demonstrating the scalability and industrial potential of the process. Additionally, the process incorporates a waste acid recycling strategy, which has no significant impact on product yield, thus enhancing economic benefits and reducing environmental pollution. This continuous nitration process not only shows broad application potential but also offers a safe and efficient solution for nitration in the pharmaceutical and chemical industries.