Application of TFPI2 in Sepsis Severity Prediction

Abstract Introduction Infection and coagulation dysfunction are two major features of sepsis, and TFPI2 exhibits both antimicrobial and anticoagulant properties. This study aims to evaluate whether TFPI2 is associated with the severity of sepsis, thereby determining its potential value in sepsis diagnosis and prognosis. Methods Serum TFPI2 concentrations were measured and compared among 32 healthy controls, 16 ICU non-sepsis patients, and 106 ICU sepsis patients. Correlation analysis was performed between various indicators and TFPI2 levels in sepsis patients. Logistic regression analysis and ROC curves were used to assess the value of TFPI2 in predicting 28-day mortality in sepsis. Results Sepsis patients exhibited markedly elevated serum TFPI2 levels compared to both healthy individuals and ICU patients without sepsis. Serum TFPI2 levels were significantly correlated with sepsis severity indicators such as SOFA, APACHE II, Lac, coagulation markers including ISTH-DIC and SIC scores, and platelet count. Univariate and multivariate logistic regression analyses revealed that TFPI2 is an independent risk factor for 28-day mortality in sepsis. The ROC curve showed that TFPI2 has a significant predictive value for 28-day mortality in sepsis, with an AUC of 0.832 and an optimal cutoff value of 8.316. Conclusions This study indicates that serum TFPI2 levels hold promise as a biomarker for predicting the severity of sepsis.