H2O2‐Driven Aggregation Induced Emission‐Based Nanomotors for the Monitoring and Treatment of Infected Surgical Wound

Abstract Post‐operative surgical wound monitoring remains a significant clinical challenge in preventing bacterial infection. Current methods rely on indirect observations or costly investigations, often detecting infections only after complications arise. Here the medical sutures coated with Janus‐type nanomotors (Pt‐MOFs) with infected microenvironment‐responsive properties for monitoring and treating surgical site infections are prepared. The Pt‐MOFs nanomotors exhibit efficient self‐propulsion with enhanced penetration and diffusion in biofilms by catalyzing hydrogen peroxide to produce oxygen bubbles. Copper ions serve dual roles as structural nodes and Fenton‐like catalysts, generating antibacterial hydroxyl radicals while forming non‐emissive self‐aggregates. Here in vitro is shown that Pt‐MOFs nanomotors present excellent bacterial imaging and enhanced antibacterial activity against both Gram‐positive and Gram‐negative bacteria. As a proof of concept, Pt‐MOFs nanomotors coated surgical sutures successfully monitor the process of Staphylococcus aureus ‐infected wounds on mouse model. Furthermore, in vivo studies testify that Pt‐MOFs nanomotors play an important role in treating infected surgical wounds through mitigating inflammatory infiltrates, facilitating collagen deposition and accelerating reepithelialization. This combined monitoring and treatment approach offers a promising strategy for surgical wound healing.