脂质体
脂类学
炎症
免疫衰老
胰岛素抵抗
老化
免疫系统
生物
神经酰胺
免疫学
糖尿病
生物信息学
生物化学
内分泌学
遗传学
细胞凋亡
作者
Daniel Hornburg,Si Wu,Mahdi Moqri,Xin Zhou,Kévin Contrepois,Nasim Bararpour,Gavin M. Traber,Baolong Su,Ahmed A. Metwally,Monica Avina,Wenyu Zhou,Jessalyn M. Ubellacker,Tejaswini Mishra,Sophia Miryam Schüssler‐Fiorenza Rose,Paula Kavathas,Kevin J. Williams,M Snyder
标识
DOI:10.1038/s42255-023-00880-1
摘要
Abstract Lipids can be of endogenous or exogenous origin and affect diverse biological functions, including cell membrane maintenance, energy management and cellular signalling. Here, we report >800 lipid species, many of which are associated with health-to-disease transitions in diabetes, ageing and inflammation, as well as cytokine–lipidome networks. We performed comprehensive longitudinal lipidomic profiling and analysed >1,500 plasma samples from 112 participants followed for up to 9 years (average 3.2 years) to define the distinct physiological roles of complex lipid subclasses, including large and small triacylglycerols, ester- and ether-linked phosphatidylethanolamines, lysophosphatidylcholines, lysophosphatidylethanolamines, cholesterol esters and ceramides. Our findings reveal dynamic changes in the plasma lipidome during respiratory viral infection, insulin resistance and ageing, suggesting that lipids may have roles in immune homoeostasis and inflammation regulation. Individuals with insulin resistance exhibit disturbed immune homoeostasis, altered associations between lipids and clinical markers, and accelerated changes in specific lipid subclasses during ageing. Our dataset based on longitudinal deep lipidome profiling offers insights into personalized ageing, metabolic health and inflammation, potentially guiding future monitoring and intervention strategies.
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