声动力疗法
光热治疗
纳米医学
癌症研究
光动力疗法
光敏剂
基质
放射治疗
免疫疗法
间质细胞
免疫
材料科学
免疫系统
医学
化学
纳米技术
纳米颗粒
免疫学
内科学
免疫组织化学
有机化学
作者
Yongjiang Li,Wei Chen,Yong Kang,Xueyan Zhen,Zhuoming Zhou,Chuang LIU,Shuying Chen,Xiangang Huang,Haijun Liu,Seyoung Koo,Na Kong,Xiaoyuan Ji,Tian Xie,Wei Tao
标识
DOI:10.1038/s41467-023-42509-7
摘要
The dense stroma of desmoplastic tumor limits nanotherapeutic penetration and hampers the antitumor immune response. Here, we report a denaturation-and-penetration strategy and the use of tin monosulfide nanoparticles (SnSNPs) as nano-sonosensitizers that can overcome the stromal barrier for the management of desmoplastic triple-negative breast cancer (TNBC). SnSNPs possess a narrow bandgap (1.18 eV), allowing for efficient electron (e-)-hole (h+) pair separation to generate reactive oxygen species under US activation. More importantly, SnSNPs display mild photothermal properties that can in situ denature tumor collagen and facilitate deep penetration into the tumor mass upon near-infrared irradiation. This approach significantly enhances sonodynamic therapy (SDT) by SnSNPs and boosts antitumor immunity. In mouse models of malignant TNBC and hepatocellular carcinoma (HCC), the combination of robust SDT and enhanced cytotoxic T lymphocyte infiltration achieves remarkable anti-tumor efficacy. This study presents an innovative approach to enhance SDT and antitumor immunity using the denaturation-and-penetration strategy, offering a potential combined sono-immunotherapy approach for the cancer nanomedicine field.
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