赖氨酸
代谢组
生物化学
蛋白质组
生物
哌啶酸
代谢组学
糖基化
新陈代谢
氨基酸
代谢物
生物信息学
受体
作者
Yimei Tan,Maria Chrysopoulou,Markus M. Rinschen
出处
期刊:Physiological Genomics
[American Physiological Society]
日期:2023-12-01
卷期号:55 (12): 579-586
标识
DOI:10.1152/physiolgenomics.00061.2023
摘要
Lysine is an essential amino acid that serves as a building block in protein synthesis. Beside this, the metabolic activity of lysine has only recently been unraveled. Lysine metabolism is tissue specific and is linked to several renal, cardiovascular, and endocrinological diseases through human metabolomics datasets. As a free molecule, lysine takes part in the antioxidant response and engages in protein modifications, and its chemistry shapes both proteome and metabolome. In the proteome, it is an acceptor for a plethora of posttranslational modifications. In the metabolome, it can be modified, conjugated, and degraded. Here, we provide an update on integrative physiology of mammalian lysine metabolites such as α-aminoadipic acid, saccharopine, pipecolic acid, and lysine conjugates such as acetyl-lysine, and sugar-lysine conjugates such as advanced glycation end products. We also comment on their emerging associative and mechanistic links to renal disease, hypertension, diabetes, and cancer.
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