细胞外基质
肌层
子宫
再生(生物学)
细胞生物学
干细胞
脚手架
子宫内膜
医学
生物
内科学
生物医学工程
作者
Long‐Mei Zhao,Lincui Da,R. Wang,Long Wang,Yanlin Jiang,Xiuzhen Zhang,Ya-xing Li,Xiongxin Lei,Yongping Song,Chen-yu Zou,Liping Huang,Wen-qian Zhang,Qing-yi Zhang,Q F Li,Rong Nie,Yi Zhang,Yan Liang,Jesse Li‐Ling,Huiqi Xie
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-11-17
卷期号:9 (46)
标识
DOI:10.1126/sciadv.adi6488
摘要
The recurrence rate for severe intrauterine adhesions is as high as 60%, and there is still lack of effective prevention and treatment. Inspired by the nature of uterus, we have developed a bilayer scaffold (ECM-SPS) with biomimetic heterogeneous features and extracellular matrix (ECM) microenvironment of the uterus. As proved by subtotal uterine reconstruction experiments, the mechanical and antiadhesion properties of the bilayer scaffold could meet the requirement for uterine repair. With the modification with tissue-specific cell–derived ECM, the ECM-SPS had the ECM microenvironment signatures of both the endometrium and myometrium and exhibited the property of inducing stem cell–directed differentiation. Furthermore, the ECM-SPS has recruited more endogenous stem cells to promote endometrial regeneration at the initial stage of repair, which was accompanied by more smooth muscle regeneration and a higher pregnancy rate. The reconstructed uterus could also sustain normal pregnancy and live birth. The ECM-SPS may thereby provide a potential treatment for women with severe intrauterine adhesions.
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