Inhibitory effects of lidocaine on colon carcinoma progression in a rat model: a pilot study

Editor—Recent data suggest that certain anaesthetic interventions have a role in reducing tumour recurrence after cancer surgery. 1 Snyder G.L. Greenberg S. Effect of anaesthetic technique and other perioperative factors on cancer recurrence. Br J Anaesth. 2010; 105: 106-115 Abstract Full Text Full Text PDF PubMed Scopus (404) Google Scholar ,2 Xing W. Chen D.T. Pan J.H. et al. Lidocaine induces apoptosis and suppresses tumor growth in human hepatocellular carcinoma cells in vitro and in a xenograft model in vivo. Anesthesiology. 2017; 126: 868-881 Crossref PubMed Scopus (107) Google Scholar For example, amide local anaesthetics have recently been shown to have inhibitory effects on cancer cells. 2 Xing W. Chen D.T. Pan J.H. et al. Lidocaine induces apoptosis and suppresses tumor growth in human hepatocellular carcinoma cells in vitro and in a xenograft model in vivo. Anesthesiology. 2017; 126: 868-881 Crossref PubMed Scopus (107) Google Scholar ,3 Chamaraux-Tran T.N. Mathelin C. Aprahamian M. et al. Antitumor effects of lidocaine on human breast cancer cells: an in vitro and in vivo experimental trial. Anticancer Res. 2018; 38: 95-105 PubMed Google Scholar Lidocaine, used perioperatively as an analgesic, 4 Weibel S. Jelting Y. Pace N.L. et al. Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults. Cochrane Database Syst Rev. 2018; 6: CD009642 PubMed Google Scholar can reduce cancer cell viability, migration, and invasion and increase apoptosis in cancer cell cultures and in animal models with various cancers. 3 Chamaraux-Tran T.N. Mathelin C. Aprahamian M. et al. Antitumor effects of lidocaine on human breast cancer cells: an in vitro and in vivo experimental trial. Anticancer Res. 2018; 38: 95-105 PubMed Google Scholar ,5 Zhang Y. Jing Y. Pan R. Ding K. Chen R. Meng Q. Mechanisms of cancer inhibition by local anesthetics. Front Pharmacol. 2021; 12770694 Crossref Scopus (17) Google Scholar ,6 Wall T.P. Crowley P.D. Sherwin A. Foley A.G. Buggy D.J. Effects of lidocaine and Src inhibition on metastasis in a murine model of breast cancer surgery. Cancers (Basel). 2019; 11: 1414 Crossref PubMed Scopus (29) Google Scholar