毒性
食品安全
风险评估
食物链
食品工业
食品添加剂
公认安全
毒理
生物技术
风险分析(工程)
业务
生物
计算机科学
化学
食品科学
生态学
计算机安全
有机化学
作者
Xing-Xing Shi,Fan Wang,Zhi-Zheng Wang,Guang-Yi Huang,Min Li,Jesús Simal-Gándara,Ge‐Fei Hao,Guang‐Fu Yang
标识
DOI:10.1080/10408398.2022.2152423
摘要
Rigorous risk assessment of chemicals in food and feed is essential to address the growing worldwide concerns about food safety. High-quality toxicological data on food-relevant chemicals are fundamental for risk modeling and assessment in the food safety area. The organization and analysis of substantial toxicity information can positively support decision-making by providing insight into toxicity trends. However, it remains challenging to systematically obtain fragmented toxicity data, and related toxicological resources are required to meet the current demands. In this study, we collected 221,439 experimental toxicity records for 5,657 food-relevant chemicals identified from extensive databases and literature, along with their information on chemical identification, physicochemical properties, environmental fates, and biological targets. Based on the aggregated data, a freely available web-based databank, Food-Relevant Available Chemicals Toxicology Databank (FRAC-TD) is presented, which supports multiple browsing ways and search criterions. Applying FRAC-TD for data-driven analysis, we revealed the underlying toxicity profiles of food-relevant chemicals in humans, mammals, and other species in the food chain. Expectantly, FRAC-TD could positively facilitate toxicological studies, toxicity prediction, and risk assessments in the food industry.
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