肺结核
结核分枝杆菌
生物
动物模型
免疫学
免疫
医学
免疫系统
病理
内分泌学
作者
Pablo Soldevilla,Cristina Vilaplana,Pere-Joan Cardona
出处
期刊:Pathogens
[MDPI AG]
日期:2022-12-28
卷期号:12 (1): 49-49
标识
DOI:10.3390/pathogens12010049
摘要
Science has been taking profit from animal models since the first translational experiments back in ancient Greece. From there, and across all history, several remarkable findings have been obtained using animal models. One of the most popular models, especially for research in infectious diseases, is the mouse. Regarding research in tuberculosis, the mouse has provided useful information about host and bacterial traits related to susceptibility to the infection. The effect of aging, sexual dimorphisms, the route of infection, genetic differences between mice lineages and unbalanced immunity scenarios upon Mycobacterium tuberculosis infection and tuberculosis development has helped, helps and will help biomedical researchers in the design of new tools for diagnosis, treatment and prevention of tuberculosis, despite various discrepancies and the lack of deep study in some areas of these traits.
科研通智能强力驱动
Strongly Powered by AbleSci AI