免疫编辑
免疫疗法
癌症
液体活检
循环肿瘤DNA
癌症免疫疗法
医学
计算生物学
免疫系统
癌症研究
生物
生物信息学
免疫学
内科学
作者
Valsamo Anagnostou,Blair V. Landon,Jamie E. Medina,Patrick M. Forde,Victor E. Velculescu
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2022-11-09
卷期号:14 (670)
被引量:12
标识
DOI:10.1126/scitranslmed.abo3958
摘要
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapeutics, triggering studies to understand the molecular and cellular wiring of response and resistance. Our increased understanding of the underlying biology of response to ICI has enabled the investigation of tumor-intrinsic and -extrinsic features that may predict therapeutic outcomes. In parallel, liquid biopsy measurements of circulating tumor DNA (ctDNA) can be used to assess real-time molecular responses and guide clinical decisions during ICI. The combination of these approaches provides a deeper understanding of cancer biology, immunoediting, and evolution during ICI and promise to extend the utility of immunotherapies for patients with cancer.
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