脱甲基酶
神经炎症
疾病
自噬
组蛋白
神经科学
表观遗传学
发病机制
阿尔茨海默病
医学
心理压抑
生物信息学
生物
基因表达
基因
免疫学
内科学
遗传学
细胞凋亡
作者
Yu Li,Yuanyuan Zhao,Xiaona Li,Liang Zhai,Hairong Zheng,Yan Yan,Qiang Fu,Junxia Ma,Haier Fu,Zhenqiang Zhang,Zhonghua Li
标识
DOI:10.3389/fphar.2022.1020556
摘要
Alzheimer's disease (AD) is a common chronic neurodegenerative disease characterized by cognitive learning and memory impairments, however, current treatments only provide symptomatic relief. Lysine-specific demethylase 1 (LSD1), regulating the homeostasis of histone methylation, plays an important role in the pathogenesis of many neurodegenerative disorders. LSD1 functions in regulating gene expression via transcriptional repression or activation, and is involved in initiation and progression of AD. Pharmacological inhibition of LSD1 has shown promising therapeutic benefits for AD treatment. In this review, we attempt to elaborate on the role of LSD1 in some aspects of AD including neuroinflammation, autophagy, neurotransmitters, ferroptosis, tau protein, as well as LSD1 inhibitors under clinical assessments for AD treatment.
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