Lactiplantibacillus plantarum ZP-6 mitigates polystyrene nanoplastics-induced liver damage in colitis mice via the gut-liver axis

Introduction: clearance. Studies have found that lactic acid bacteria has the potential to eliminate pollutants from the body. Methods: ZP-6 to alleviate the physiological toxicity of polystyrene nanoplastics (PS-NPs) in healthy and colitic murine models. Results: ), reinforcing the intestinal epithelial barrier and impeding PS-NPs translocation. Metabolomic analysis further indicated that ZP-6 rectified PS-NPs-induced hepatic metabolic dysregulation via the gut-liver axis. Conclusion: These results elucidate a multifaceted probiotic mechanism for NPs detoxification, providing a promising translational strategy to counteract nanoplastic-related health hazards.