Brain targeting for the treatment of obesity: update of current knowledge and potential applications of nanomedicine and peptide conjugation

Based on literature review, nanocarriers and conjugation strategies can offer targeted delivery of both natural molecules and peptides, enhancing their therapeutics, improving cellular uptake, and regulating metabolism and inflammatory pathways. The choice of the proper administration route, along with a delivery strategy significantly impacts the pharmacokinetics and therapeutic outcomes of compounds delivered through nanomedicines and encourages their translation 'from bench to bedside.'