Metastatic HER2-amplified non-small-cell lung cancer treated with trastuzumab deruxtecan

Human epidermal growth factor receptor 2 (HER2) alterations can occur as gene mutations, gene amplification or protein overexpression. DESTINY-Lung01 and DESTINY-Lung02 demonstrated the efficacy of trastuzumab deruxtecan in the subsequent line setting in patients with unresectable or metastatic HER2 -mutated non-small-cell lung cancer (NSCLC). Trastuzumab deruxtecan has not been studied in select patients with HER2 -amplified NSCLC. Here, we present the first reported case of metastatic HER2 -amplified NSCLC treated with trastuzumab deruxtecan with a durable response to therapy.