医学
肿瘤科
内科学
异柠檬酸脱氢酶
胶质瘤
化疗
比例危险模型
危险系数
队列
O-6-甲基鸟嘌呤-DNA甲基转移酶
前瞻性队列研究
甲基转移酶
甲基化
癌症研究
置信区间
生物
遗传学
基因
酶
生物化学
作者
Connor J. Kinslow,Ann Mercurio,Prashanth Kumar,Ali I. Rae,Markus D. Siegelin,Jack Grinband,Kekoa Taparra,Pavan S. Upadhyayula,Guy M. McKhann,Michael B. Sisti,Jeffrey N. Bruce,Peter Canoll,Fábio M. Iwamoto,Lisa A. Kachnic,James B. Yu,Simon K. Cheng,Tony J. C. Wang
出处
期刊:JAMA Oncology
[American Medical Association]
日期:2023-05-18
卷期号:9 (7): 919-919
被引量:44
标识
DOI:10.1001/jamaoncol.2023.0990
摘要
This study suggests that mMGMT is associated with response to alkylating chemotherapy for low-grade and anaplastic gliomas and may be considered as a stratification factor in future clinical trials of patients with IDH-wild-type and IDH-mutant and codeleted tumors.
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