医学
背根神经节
神经营养因子
脑源性神经营养因子
刺激
止痛药
麻醉
脊髓
周围神经病变
神经生长因子
药理学
神经病理性疼痛
伤害
外围设备
内科学
内分泌学
受体
精神科
糖尿病
作者
Dong-Wook Kang,Jae-Gyun Choi,Hee Ju Song,Jaehyuk Kim,Miae Lee,Tae-Hee Kim,Sung-Soo Kang,Yeonhee Ryu,Hwa Seung Yoo,Jin Sung Lee,Jin Bong Park,Sang Do Lee,Hyun Woo Kim
出处
期刊:PubMed
日期:2023-08-01
卷期号:43 (4): 686-694
标识
DOI:10.19852/j.cnki.jtcm.2023.04.005
摘要
Chemotherapeutic agents such as docetaxel (DTX) can trigger chemotherapy-induced peripheral neuropathy (CIPN), which is characterized by unbearable pain. This study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation (LFMNS) on DTX-induced tactile hypersensitivity in mice.To produce CIPN, DTX was administered intraperitoneally 4 times, once every 2 d, to male ICR mice. LFMNS was performed on the wrist area, and the pain response was measured using von Frey filaments on both hind paws. Western blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brain-derived neurotrophic factor (BDNF).Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal area.LFMNS might be an effective non-pharmaceutical option for treating patients suffering from CIPN regulating the expression of peripheral and central BDNF.
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