Demographic Patterns and Clinicopathological Analysis of Sarcomatoid Renal Cell Carcinoma in US Population

Background Sarcomatoid renal cell carcinoma (RCC) is defined by the presence of any amount of sarcomatoid components admixed with other RCC histologic subtypes. Our investigation utilizes a large, diverse set of sarcomatoid RCC patients to summarise clinical, demographic, and pathological factors along with demographic disparities that may affect the prognosis and survival of sarcomatoid RCC patients. Methods The Surveillance, Epidemiology, and End Results (SEER) database was employed to compile data from 2000-2018 from 2,695 patients diagnosed with sarcomatoid RCC. Results The mean age for sarcomatoid RCC diagnosis is 62.8 years. Males (68.2%) and White patients (82.6%) were more likely to be diagnosed with sarcomatoid RCC. Among the 64.4% of tumors with known size, 35.4% were less than 7 cm, 27.6% were 7.1-10 cm, and 36.4% were larger than 10 cm. Among the 95.8% of patients with known stage, 15.3% were localized, 28.9% were regionalized, and 55.8% were found in distant sites. Among the 44.2% of cases with known metastases site, lung was found to be the most common metastatic site.. Surgery was the most common treatment (70.9%). While the overall 5-year survival was 18.1%, it was 27.1% among patients who underwent surgery. Independent risk factors for mortality include age > 60 years, distant stage, and tumor size > 10 cm, per our multivariate analysis. Conclusion Sarcomatoid RCC most commonly affects White males in their seventh decade. Increased age, distant stage, and size > 10 cm tumor size have associations with unfavorable prognosis. Surgery is associated with better survival outcomes in localized disease and multimodal therapy (surgery with adjuvant chemoradiation was associated with better survival.. Macro abstract The Surveillance, Epidemiology, and End Results (SEER) database was used to extract data for sarcomatoid-RCC. The mean age for sarcomatoid RCC diagnosis is 62.8 years. Males (68.2%) White patients (82.6%) were more likely to be diagnosed with sarcomatoid RCC. 55.8% were found to have distant disease at presentation. 36.4% cases had tumor size were larger than 10 cm. Surgery is the most common treatment 70.9%. The overall 5-year survival was 18.1%, increasing to 27.1% among patients who underwent surgery. Independent risk factors for mortality include age > 60 years, distant stage, and > 10 cm tumor size, according to multivariate analysis.