膜
材料科学
中空纤维膜
化学工程
表面改性
聚砜
色谱法
渗透
体外循环
涂层
人工肺
化学
复合材料
聚合物
外科
工程类
神经科学
生物
医学
生物化学
作者
Donghai Sheng,Lin Zhang,Hao Jia,Bing Guo,Xiangjun Zhang,Yuan Li
出处
期刊:Langmuir
[American Chemical Society]
日期:2023-07-10
卷期号:39 (28): 9796-9807
被引量:2
标识
DOI:10.1021/acs.langmuir.3c00945
摘要
As the key component of extracorporeal membrane oxygenation (ECMO), artificial lung membranes have low gas permeability and plasma leakage problems, and the contact between membrane materials and blood can cause coagulation, leading to the blockage of medical equipment and seriously threatening the safety of human life. In our work, poly(4-methyl-1-pentene) hollow fiber membranes (PMP HFMs) were prepared by the thermally induced phase separation (TIPS) method, the redox method was adopted for the surface hydroxylation of PMP HFMs, and then, heparin (Hep) and 2-(methacryloyloxy)ethyl(2-(trimethylammonio)ethyl) phosphate (MPC) were grafted to the surface of PMP HFMs to prepare anticoagulant coatings. The gas permeability and hemo-compatibility of the coatings were investigated by various characterization methods, such as gas flow meter, scanning electron microscope, extracorporeal circulation experiment, etc. The results show that PMP HFMs possess a bicontinuous pore structure with a dense surface layer, which could maintain good gas permeability with an oxygen permeance of 0.8 mL/bar·cm2·min and stable gas selectivity. Furthermore, the whole blood circulation of rabbit indicated that a composite surface of bioactive Hep and biopassive MPC might be used as artificial lung membranes without the formation of thrombosis within 21 days.
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