细菌
磷酸盐
铜
材料科学
水解
抗菌活性
灭菌(经济)
核化学
化学
生物化学
生物
冶金
外汇
货币经济学
外汇市场
经济
遗传学
作者
Zheng Wang,Yue Zhang,Xinyu Qu,Feng Chen,Xinyu Zhao
标识
DOI:10.1016/j.ceramint.2023.03.140
摘要
The rapid development of antibiotic resistance poses a huge threat to human health. Copper-based materials is a promising alternative to the traditional antibiotics due to its high efficacy and low resistance potential for bacterial infections. In this work, three-dimensional flower-like copper hydrogen phosphate nanosheet assembled microspheres (CP-NSMSs) are synthesized through a hydrolysis-assisted synthetic method using fructose-1,6-diphosphate (FDP) as the organic phosphate source. The copper hydrogen phosphate nanosheets with high aspect ratio provide a large amount of sharp edges which could penetrate bacterial membranes, resulting in the death of bacteria. Furthermore, the as-prepared CP-NSMSs exhibit the high peroxidase-like activity producing a large amount of reactive oxygen species (ROS) to kill bacteria. Based on the in vitro bacterial growth experiments, our CP-NSMSs show an excellent sterilization effect against both Gram-positive and Gram-negative bacteria. Therefore, the CP-NSMSs synthesized using the FDP as an organic phosphate source is expected to be a promising antibacterial agent with minimum resistance potential.
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