荧光
激进的
化学
水溶液
赫拉
光化学
羟基自由基
超声波
体外
有机化学
生物化学
光学
声学
物理
作者
Cherie Wong,Lu-Lu Sun,Mengjiao Liu,Eleanor Stride,Jason L. Raymond,Hai‐Hao Han,James Kwan,Adam C. Sedgwick
摘要
We report the synthesis of hydroxyl-radical (˙OH) responsive fluorescent probes that utilise the 3,5-dihydroxybenzyl (DHB) functionality. 4-Methylumbeliferone-DHB (Umb-DHB) and resorufin-DHB (Res-DHB) in the presence of ˙OH radicals resulted in significant increases in their respective fluorescent emission intensities at 460 nm and 585 nm. The incubation of Res-DHB in HeLa cells followed by therapeutic ultrasound (1 MHz) resulted in a significant increase in fluorescence emission intensity thus permitting the ability to monitor ultrasound-induced ˙OH production in live cells.
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