拟南芥
磷酸化
植物生长
细胞生物学
计算生物学
化学
生物
计算机科学
生物化学
植物
基因
突变体
作者
Christian Wiese,Miriam Abele,Benjamin Al,Melina Altmann,Alexander Steiner,Nils Kalbfuß,Alexander Strohmayr,Raksha Ravikumar,Chan Ho Park,Barbara Brunschweiger,Chen Meng,Eva Facher,David W Ehrhardt,Pascal Falter‐Braun,Wenfei Wang,Christina Ludwig,Farhah F. Assaad
标识
DOI:10.1083/jcb.202311125
摘要
Plants often adapt to adverse or stress conditions via differential growth. The trans-Golgi network (TGN) has been implicated in stress responses, but it is not clear in what capacity it mediates adaptive growth decisions. In this study, we assess the role of the TGN in stress responses by exploring the previously identified interactome of the Transport Protein Particle II (TRAPPII) complex required for TGN structure and function. We identified physical and genetic interactions between AtTRAPPII and shaggy-like kinases (GSK3/AtSKs) and provided in vitro and in vivo evidence that the TRAPPII phosphostatus mediates adaptive responses to abiotic cues. AtSKs are multifunctional kinases that integrate a broad range of signals. Similarly, the AtTRAPPII interactome is vast and considerably enriched in signaling components. An AtSK–TRAPPII interaction would integrate all levels of cellular organization and instruct the TGN, a central and highly discriminate cellular hub, as to how to mobilize and allocate resources to optimize growth and survival under limiting or adverse conditions.
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