彭布罗利珠单抗
医学
胸腺瘤
免疫检查点
免疫组织化学
PD-L1
肺癌
封锁
胸腺癌
免疫系统
癌症
内科学
肿瘤科
免疫疗法
病理
受体
免疫学
作者
Thilo Zander,Stefan Aebi,Anna Christina Rast,Andrea Zander,Ralph Winterhalder,Christoph U. Brand,Joachim Diebold,Oliver Gautschi
标识
DOI:10.1016/j.jtho.2016.07.018
摘要
The interaction of programmed death ligand 1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) results in critical inhibition of the immune system. 1 Weber J. Immune checkpoint proteins: a new therapeutic paradigm for cancer—preclinical background: CTLA-4 and PD-1 blockade. Semin Oncol. 2010; 37: 430-439 Abstract Full Text Full Text PDF PubMed Scopus (228) Google Scholar PD-L1 expression was recently reported in thymic epithelial tumors (TETs) and associated with aggressive histologic subtype and poor prognosis. 2 Padda S.K. Riess J.W. Schwartz E.J. et al. Diffuse high intensity PD-L1 staining in thymic epithelial tumors. J. Thorac Oncol. 2016; 10: 500-508 Abstract Full Text Full Text PDF Scopus (91) Google Scholar , 3 Katsuya Y. Fujita Y. Horinouchi H. Ohe Y. Watanabe S ichi Tsuta K. Immunohistochemical status of PD-L1 in thymoma and thymic carcinoma. Lung Cancer. 2015; 88: 154-159 Abstract Full Text Full Text PDF PubMed Scopus (114) Google Scholar
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