Peroxisome Proliferator-Activated Receptors and Inflammation

AbstractThe peroxisome proliferator-activated receptors belong to the superfamily of nuclear receptors which produce their effects, in part, by regulation of gene transcription. There are three peroxisome proliferator-activated receptor (PPAR) isoforms; α, δ (also known as β), and γ, which are activated by a numerous ligands including endocannabinoids. Activation of these receptors has been shown to modulate inflammation, in a number of different animal models. This chapter discusses the evidence that PPAR activation modulates inflammation, inflammatory processes, and immune cell infiltration, as well as reports of adverse effects of PPAR activation, which may have an impact on the therapeutic potential of PPAR agonists as anti-inflammatory agents.KeywordsChronic Constriction InjuryExperimental Allergic EncephalomyelitisFatty Acid Amide HydrolaseGlyceryl EtherImmune Cell InfiltrationThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.