基因组
基因
计算生物学
生物
通路分析
癌症
遗传学
基因表达
作者
Pau Creixell,Jüri Reimand,Syed Haider,Guanming Wu,Tatsuhiro Shibata,Miguel Vazquez,Ville Mustonen,Abel Gonzalez-Perez,John V. Pearson,Chris Sander,Rune Linding
出处
期刊:Nature Methods
[Springer Nature]
日期:2015-06-30
卷期号:12 (7): 615-621
被引量:284
摘要
Genomic information on tumors from 50 cancer types cataloged by the International Cancer Genome Consortium (ICGC) shows that only a few well-studied driver genes are frequently mutated, in contrast to many infrequently mutated genes that may also contribute to tumor biology. Hence there has been large interest in developing pathway and network analysis methods that group genes and illuminate the processes involved. We provide an overview of these analysis techniques and show where they guide mechanistic and translational investigations.
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