Enhancing exosomes efficacy with engineered nanozymes for a multi-targeted combination strategy in osteoarthritis treatment

/Gel). This formulation significantly reduced inflammation, chondrocyte ferroptosis, cartilage degeneration, and subchondral bone remodeling, ultimately slowing OA progression. With excellent biocompatibility, this innovative combinatorial therapeutic strategy represents a comprehensive approach for enhancing Exo efficacy in OA treatment with promising translational potential.