Electrochemical Synthesis of 1,2-Substituted N -Amido Benzimidazoles by Reduction of Nitroarenes

High Resolution Image Download MS PowerPoint Slide Despite the vast number of reports on benzimidazoles, 1,2-substituted N -amido benzimidazoles remain an underrepresented and scarcely accessible compound class with promising pharmacological relevance. We present a safe, reliable electrochemical protocol that provides easy access to those structures. The reaction exhibits broad functional group tolerance and affords the target compounds in ≤89% yields.