Network control through coordinated inhibition

Coordinated excitatory and inhibitory activity is required for proper brain functioning. Recent computational and experimental studies have demonstrated that activity patterns in recurrent cortical networks are dominated by inhibition. Whereas previous studies have suggested that inhibitory plasticity is important for homeostatic control, this new framework puts inhibition in the driver's seat. Complex neuronal networks in the brain comprise many configurations in parallel, controlled by external and internal 'switches'. Context-dependent modulation and plasticity of inhibitory connections play a key role in memory and learning. It is therefore important to realize that synaptic plasticity is often multisynaptic and that a proper balance between excitation and inhibition is not fixed, but depends on context and activity level.