医学
射血分数
心脏病学
内科学
沙库比林、缬沙坦
沙库比林
心力衰竭
缬沙坦
射血分数保留的心力衰竭
冲程容积
利钠肽
血压
作者
Yanis Bouali,Erwan Donal,Alban Gallard,Clément Laurin,Arnaud Hubert,Auriane Bidaut,Christophe Leclercq,Elena Galli
标识
DOI:10.1016/j.amjcard.2020.03.031
摘要
The noninvasive assessment of myocardial work (MW) by pressure-strain loops analysis (PSL) is a relative new tool for the evaluation of myocardial performance. Sacubitril/Valsartan is a treatment for heart failure with reduced ejection fraction (HFrEF) which has a spectacular effect on the reduction of cardiovascular events (major adverse cardiovascular events [MACEs]). This study aimed to evaluate the short- and medium-term effect of Sacubitril/Valsartan treatment on MW parameters and the prognostic value of MW in this specific group of patients. Seventy-nine patients with HFrEF (mean age: 66 ± 12 years; LV ejection fraction: 28% ± 9%) were prospectively included in the study and treated with Sacubitril/Valsartan. Echocardiographic examination was performed at baseline, and after 6- and 12-month of therapy with Sacubitril/Valsartan. Sacubitril/Valsartan significantly increased myocardial constructive work (CW) (1023 ± 449 vs 1424 ± 484 mm Hg%, p
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