Direct Assembly of Polysubstituted Propiolamidinates via Palladium-Catalyzed Multicomponent Reaction of Isocyanides

A straightforward approach for the assembly of different polysubstituted propiolamidnates via palladium-catalyzed multicomponent reaction of isocyanides, haloalkynes, and amines has been reported in which the C(sp)–C(sp 2 ) and C(sp 2 )═N bonds were constructed in one pot. This reaction featured in high efficiency, excellent chemoselectivity, and good functional group compatibility. The synthetic utility of this method was also demonstrated.