光热治疗
生物相容性
材料科学
壳聚糖
聚乙烯醇
伤口敷料
抗菌剂
生物医学工程
纳米技术
化学
医学
复合材料
有机化学
冶金
作者
Thi Tuong Vy Phan,Thanh‐Canh Huynh,Junghwan Oh
出处
期刊:Polymers
[MDPI AG]
日期:2019-10-14
卷期号:11 (10): 1679-1679
被引量:22
标识
DOI:10.3390/polym11101679
摘要
Wound infection is a big issue of modern medicine because of multi-drug resistance bacteria; thus, developing an advanced therapy is curial. Photothermal therapy (PTT) is a newly noninvasive strategy that employs PTT agents to transfer near-infrared (NIR) light energy into heat to kill bacterial pathogens. In this work, the PTT agent-containing dressing was developed for the first time to treat the wound infection. Palladium nanoparticles (PdNPs) were chosen as PTT agents because of their high stability, good biocompatibility, excellent photothermal property, and simple-green preparation. With the flexibility and wettability, highly porous membrane chitosan/polyvinyl alcohol (CS/PVA) membrane was chosen as the dressing. The prepared wound dressings exhibited excellent biocompatibility, high porosity, a high degree of swelling, high moisture retention, and high photothermal performance. The treatment of PdNPs loading CS/PVA dressing (CS/PVA/Pd) and laser irradiation killed most of the bacteria in vitro. The proposed PTT agent containing wound dressing introduces a novel strategy for the treatment of wound infection.
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