细胞生物学
细胞器
细胞内
胞吐
膜
细胞质
生物学中的钙
细胞外
小泡
细胞
化学
生物
细胞膜
生物化学
作者
Matthias Corrotte,Thiago Castro-Gomes
出处
期刊:Current Topics in Membranes
日期:2019-01-01
卷期号:: 1-16
被引量:34
标识
DOI:10.1016/bs.ctm.2019.08.001
摘要
The ability of repairing damages on the plasma membrane is crucial for cell survival. When damaged, eukaryotic cells are able to recover plasma membrane integrity within a few seconds, thus avoiding cytoplasm leakage and cell death. The process is driven by the influx of extracellular calcium which triggers a multitude of intracellular effects that participate in the process of plasma membrane resealing. One of the landmarks of plasma membrane repair is the triggering of intracellular vesicles recruitment and their exocytosis at damage sites. Since lysosomes are able to respond to calcium influx and that some of the lysosomal enzymes exocytosed after plasma membrane permeabilization are essential to restore cell integrity, these organelles have emerged as essential for the maintenance of plasma membrane integrity. Here we summarize the scientific evidences showing the involvement of lysosomes in plasma membrane repair that allowed researchers to propose a totally different function for this famous organelle.
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